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Published on: December 31, 2017
Chronic oral disease burden at the first 1000 days: Intergenerational risk factors, BRISA cohort
Sângela Maria Pereira Araújo1, Gustavo G Nascimento2,3,4, Lorena Lucia Costa Ladeira1
1Postgraduate Program of Dentistry, Federal University of Maranhão, São Luís, Maranhão, Brazil.
Insights
Maternal obesity and sugar intake impact offspring oral health, increasing the risk of chronic oral disease burden. Early life oral health is critical for long-term well-being and may predict non-communicable diseases.
Area of Science:
- Public Health
- Maternal and Child Health
- Oral Epidemiology
Background:
- The first 1000 days of life are critical for development and disease prevention.
- Oral health during pregnancy and early childhood is linked to long-term health outcomes.
- Understanding intergenerational factors influencing oral health is crucial for public health interventions.
Purpose of the Study:
- To analyze multiple-causal models of oral disease burden in offspring.
- To investigate the intergenerational impact of maternal socioeconomic, obesity, and lifestyle factors on offspring oral health.
- To examine the association between maternal oral health (caries, periodontitis) and offspring's early sugar exposure and overweight status.
Main Methods:
- Utilized data from the BRISA cohort study in Brazil (n=1141).
- Employed structural equation modeling to analyze associations between maternal and child variables.
- Assessed oral health indicators, obesity, sugar consumption, smoking, and alcohol use at two time points: pregnancy and child's second year.
Main Results:
- Maternal obesity (SC=0.081, p=0.047) and added sugar consumption (SC=0.142, p=0.041) showed intergenerational correlations.
- Childhood sugar consumption (SC=0.210, p=0.041) significantly increased the Chronic Oral Disease Burden.
- Caries and periodontitis in pregnant women were correlated, as were addictive behaviors during gestation.
Conclusions:
- Oral health conditions like caries and periodontitis in pregnant women are linked to those in their offspring.
- Obesity and sugar consumption patterns are transmitted across generations, impacting early childhood oral health.
- Early life oral health is a significant predictor of future non-communicable diseases, influencing life trajectories.
Objective:
To analyze multiple-causal models, including socioeconomic, obesity, sugar consumption, alcohol smoking, caries, and periodontitis variables in pregnant women with early sugar exposure, obesity, and the Chronic Oral Disease Burden in their offspring around the first 1000 days of life.
Methods:
The BRISA cohort study, Brazil, had two assessments: at the 22nd-25th gestational weeks and during the child's second year (n = 1141). We proposed a theoretical model exploring the association between socioeconomic and pregnancy factors (age, smoking, alcohol, sugars, obesity, periodontitis, and caries) and child's variables (sugars and overweight) with the outcome, Chronic Oral Disease Burden (latent variable deduced from visible plaque, gingivitis, and tooth decay), using structural equation modeling.
Results:
Caries and periodontitis were correlated in pregnant women. Addictive behaviors in the gestational period were correlated. Obesity (Standardized coefficient - SC = 0.081; p = 0.047) and added sugar consumption (SC = 0.142; p = 0.041) were observed intergenerationally in the pregnant woman-child dyads. Sugar consumption by the children (SC = 0.210; p = 0.041) increased the Chronic Oral Disease Burden.
Conclusions:
Poor caries and periodontal indicators were correlated in pregnant women and their offspring. Obesity and sugar consumption act intergenerationally. Oral health in early life may change life trajectory since the worst oral conditions predict main NCDs.
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