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Age-dependent functional development pattern in neonatal brain: An fMRI-based brain entropy study.

Zhiyong Zhao1, Yifan Shuai2, Yihan Wu3

  • 1Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Neuroimage
|June 9, 2024
PubMed
Summary
This summary is machine-generated.

Brain entropy (BEN) measured by fMRI indicates age-dependent functional development in neonates. This neuroimaging marker is influenced by genes and shows differences in preterm infants.

Keywords:
AgeBrain entropyEarly developmentGeneNeonatefMRI

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Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Genetics

Background:

  • Animal studies link brain entropy (BEN) to early brain development.
  • Human neonatal brain functional changes and the genetic basis of BEN require further investigation.

Purpose of the Study:

  • To determine if BEN can identify age-dependent functional changes in human neonatal brains.
  • To elucidate the genetic underpinnings of BEN as a neuroimaging marker.

Main Methods:

  • Analysis of resting-state fMRI data from 280 infants (37.5-43.5 weeks postmenstrual age) from the Developing Human Connectome Project.
  • Calculation of BEN maps and voxel-wise general linear model analysis for age, sex, and preterm birth effects.
  • Correlation analysis between regional BEN and gene expression levels.

Main Results:

  • BEN along the sensorimotor-auditory ('S-A') axis positively correlated with postnatal age (PNA) and negatively with gestational age (GA).
  • BEN in the right rolandic operculum correlated with both GA and PNA.
  • Preterm infants showed increased cortical BEN, particularly in the visual-motor cortex, compared to term infants.
  • Five BEN-related genes (DNAJC12, FIG4, STX12, CETN2, IRF2BP2) involved in protein folding, synaptic vesicle transport, and cell division were identified.

Conclusions:

  • fMRI-based BEN serves as an indicator of age-dependent brain functional development in human neonates.
  • Specific genes influence BEN, highlighting a genetic component to this neuroimaging marker.