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Updated: May 5, 2026
Mosaic Analysis of Gene Function in Postnatal Mouse Brain Development by Using Virus-based Cre Recombination
Published on: August 1, 2011
Building the brain mosaic: an expanded view
Sahibjot Sran1, Amanda Ringland1, Tracy A Bedrosian2
1Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Abstract:
The complexity of the brain is closely tied to its nature as a genetic mosaic, wherein each cell is distinguished by a unique constellation of somatic variants that contribute to functional and phenotypic diversity. Postzygotic variation arising during neurogenesis is recognized as a key contributor to brain mosaicism; however, recent advances have broadened our understanding to include sources of neural genomic diversity that develop throughout the entire lifespan, from embryogenesis through aging. Moving beyond the traditional confines of neurodevelopment, in this review, we delve into the complex mechanisms that enable various origins of brain mosaicism.
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