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Updated: May 5, 2026

Mosaic Analysis of Gene Function in Postnatal Mouse Brain Development by Using Virus-based Cre Recombination

Mosaic Analysis of Gene Function in Postnatal Mouse Brain Development by Using Virus-based Cre Recombination

Published on: August 1, 2011

Building the brain mosaic: an expanded view.

Sahibjot Sran¹, Amanda Ringland¹, Tracy A Bedrosian²

¹Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Trends in Genetics : TIG

|June 9, 2024

Summary

This summary is machine-generated.

Brain complexity arises from its genetic mosaic nature, with cells having unique somatic variants. This review explores diverse origins of brain mosaicism throughout life, from development to aging.

Keywords:

clonal lineages development embryogenesis neurogenesis selection, reversion

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Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

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Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

Published on: May 8, 2020

Area of Science:

Neuroscience
Genetics
Cell Biology

Background:

The brain's intricate functions are linked to its genetic mosaicism, where individual cells possess distinct somatic variants.
Postzygotic variations during neurogenesis are known contributors to this mosaicism.
Recent research expands the understanding of neural genomic diversity across the entire lifespan.

Purpose of the Study:

To review the complex mechanisms underlying various origins of brain mosaicism.
To integrate knowledge beyond neurodevelopmental stages.

Main Methods:

Literature review of recent advances in understanding brain mosaicism.
Synthesis of information on somatic variants and neural genomic diversity.

Main Results:

Brain mosaicism originates from multiple sources beyond early development.
Genomic diversity arises throughout the lifespan, from embryogenesis to aging.
Complex mechanisms contribute to the spectrum of brain mosaicism.

Conclusions:

Brain complexity is fundamentally shaped by its genetic mosaic nature.
Understanding mosaicism requires considering its origins throughout life.
Further research into these mechanisms is crucial for comprehending brain function and diversity.