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Genetic polymorphisms linked to extreme postorthodontic external apical root resorption in Koreans
Jing Liu1, Kwanwoo Park2, Yoon Jeong Choi1
1Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Korea.
Progress in Orthodontics
|June 9, 2024
Summary
Genetic variations in specific genes are linked to severe external apical root resorption (EARR) during orthodontic treatment in Koreans. This research aids in developing tools to predict significant EARR risk.
Area of Science:
- Genetics
- Orthodontics
- Dental Research
Background:
- External apical root resorption (EARR) is a frequent complication of orthodontic therapy.
- Identifying genetic factors influencing extreme EARR is crucial for patient management.
Purpose of the Study:
- To identify genetic polymorphisms associated with susceptibility to extreme orthodontic-induced EARR in a Korean population.
- Utilize extreme phenotype analysis for targeted genetic investigation.
Main Methods:
- Genomic DNA was extracted from saliva of 77 orthodontic patients.
- Patients were categorized into significant resorption (≥4 mm) and normal (<2 mm) groups.
- Targeted next-generation sequencing and logistic regression analyzed single nucleotide polymorphisms (SNPs) and haplotypes.
Main Results:
- Eleven SNPs in genes TNFSF11, TNFRSF11B, WNT3A, SFRP2, LRP6, P2RX7, and LRP1 showed significant association with severe EARR (p<0.05).
- A specific P2RX7 haplotype (CCA) was more frequent in the severe resorption group.
Conclusions:
- Extreme phenotype analysis successfully identified genetic markers linked to severe EARR in the Korean population.
- These findings support the development of predictive diagnostic tools for severe root resorption during orthodontics.
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