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Stop Ischemic Event to the Brain: Screening Risk Factors of Cerebrovascular Stenosis in Coronary Artery Disease
Shi-Chang Yang1, Xing-Wen Zhang, Xi-Ting Nie
1Department of Neurology, General Hospital of the Chinese People's Liberation Army, Beijing, China.
Insights
Coronary artery disease (CAD) patients with higher onset age and hypertension are at greater risk for ischemic cerebrovascular disease (ICVD). Managing hypertension and diabetes is key for ICVD prevention in CAD patients.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Public Health
Background:
- Coronary artery disease (CAD) and ischemic cerebrovascular disease (ICVD) share common risk factors.
- Identifying specific risk factors for ICVD in CAD patients is crucial for targeted screening and prevention.
- Understanding these differences can optimize healthcare resource allocation.
Purpose of the Study:
- To investigate the distinct risk factors for ICVD in patients with CAD.
- To determine which CAD patients require ICVD-related screening.
- To enhance the primary prevention strategies for ICVD in the CAD population.
Main Methods:
- Retrospective review of clinical data from 326 first-episode CAD patients.
- Analysis of clinical features and laboratory examinations.
- Detection of intracranial and carotid arterial stenosis, and analysis of risk factors for ICVD.
Main Results:
- Patients with intracranial artery stenosis showed significant differences in onset age, hypertension, and duration of hypertension compared to non-stenosis subgroups.
- Biochemical indicators like high-density lipoprotein and glycosylated hemoglobin differed significantly between stenosis groups.
- Onset age, glycosylated hemoglobin, blood glucose, and cardiovascular stenosis degree were associated with ICVD risk.
Conclusions:
- Onset age is a critical risk factor for ICVD in CAD patients.
- Effective management of hypertension and diabetes is essential for the primary prevention of ICVD in this cohort.
- Targeted screening for ICVD should be considered for older CAD patients with hypertension and diabetes.
Objectives:
In this study, we investigated the difference in risk factors between the 2 diseases, aiming to further clarify who needs to do ischemic cerebrovascular disease (ICVD)-related screening among coronary artery disease (CAD) patients.
Methods:
Clinical data of 326 patients with first-episode CAD from June 1, 2017, to July 31, 2020, in the Chinese PLA General Hospital were retrospectively reviewed. Outcomes, including clinical features and laboratory examination, were taken. Features related to ICVD including the extension of intracranial arterial (internal carotid artery intracranial segment, middle cerebral artery M1 segment, anterior cerebral A1 segment, vertebrobasilar artery intracranial segment, posterior cerebral artery P1 segment) and carotid arterial (internal carotid artery extracranial segment, common carotid artery, subclavian artery) stenosis were detected. Risk factors for the occurrence of ICVD in patients with CAD were analyzed.
Results:
Among patients with the onset of CAD, in comparison of the nonstenosis and stenosis of intracranial artery subgroups, there were statistical differences in the onset age, hypertension, and duration of hypertension as well as the biochemical indicators, including high-density lipoprotein and glycosylated hemoglobin. In addition, statistical differences were detected in the onset age as well as the biochemical indicators, including glycosylated hemoglobin and blood glucose serum protein, along with the difference in the degree of cardiovascular stenosis.
Conclusions:
The onset age of CAD was shown to serve as a vital risk factor for ICVD. The primary prevention of ICVD in patients with CAD should lay more emphasis on the management of hypertension and diabetes.
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