Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relapsing polychondritis.

J W White

    Southern Medical Journal
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Relapsing polychondritis involves cartilage inflammation affecting multiple organs. Antibodies to type II collagen suggest an autoimmune role, with corticosteroids and dapsone showing treatment efficacy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The utility of behavioral biometrics in user authentication and demographic characteristic detection: a scoping review.

    Systematic reviews·2024
    Same author

    Influence of protogynous sex change on recovery of fish populations within marine protected areas.

    Ecological applications : a publication of the Ecological Society of America·2020
    Same author

    Introducing the GRACEnet/REAP Data Contribution, Discovery, and Retrieval System.

    Journal of environmental quality·2013
    Same author

    Connectivity and resilience of coral reef metapopulations in marine protected areas: matching empirical efforts to predictive needs.

    Coral reefs (Online)·2012
    Same author

    Management of severe Dupuytren's contracture of the proximal interphalangeal joint with use of a central slip facilitation device.

    The Journal of hand surgery, European volume·2012
    Same author

    Pile mixing increases greenhouse gas emissions during composting of dairy manure.

    Bioresource technology·2010
    Same journal

    The Five Essential Concepts of Developmental Medicine: A Medical Paradigm for People with Developmental Disabilities.

    Southern medical journal·2026
    Same journal

    α-Gal Syndrome in the South: Why We Need Treatment Trials, Not Just Tick Prevention.

    Southern medical journal·2026
    Same journal

    Association between Main Pancreatic Duct Size, Comorbidities, and Fistula Formation after Whipple Procedure for Pancreatic Cancer.

    Southern medical journal·2026
    Same journal

    Impact of Temperature Variation on Patients with Acute Severe Asthma.

    Southern medical journal·2026
    Same journal

    Assessing the Accuracy and Reliability of ChatGPT-4 to Answer Clinical EHR Messages in Sports Medicine.

    Southern medical journal·2026
    Same journal

    Diagnostic Utility and Clinical Implications of Inpatient Fecal Occult Blood Testing.

    Southern medical journal·2026
    See all related articles

    Area of Science:

    • Rheumatology
    • Immunology
    • Dermatology

    Background:

    • Relapsing polychondritis (RP) is a rare multisystem inflammatory disorder.
    • Cartilaginous structures of the ears, nose, joints, and respiratory tract are primarily affected.
    • Cutaneous manifestations are the initial presentation in over half of patients.

    Purpose of the Study:

    • To describe the clinical features of relapsing polychondritis.
    • To investigate the immunological basis of the disease.
    • To evaluate potential treatment strategies.

    Main Methods:

    • Clinical case review and analysis.
    • Immunological assays for antibodies to collagen and cartilage.
    • Assessment of treatment outcomes.

    Related Experiment Videos

    Main Results:

    • Skin involvement presents as erythema, swelling, and pain, or as vasculitis and nonspecific eruptions.
    • Circulating antibodies to native type II collagen and human fetal cartilage were detected.
    • Immune complexes were present, suggesting an antibody-mediated pathogenesis.
    • Systemic corticosteroids and dapsone demonstrated effectiveness.

    Conclusions:

    • Relapsing polychondritis is characterized by inflammation of cartilaginous tissues with significant cutaneous involvement.
    • Antibody production against type II collagen and cartilage is implicated in RP pathogenesis.
    • Corticosteroids and dapsone represent the most effective therapeutic options currently available.