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Related Experiment Video

Updated: Jun 24, 2025

Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism
08:03

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Twiddler's Syndrome.

Vincent Sneyers1, Bjorn Valgaeren2, Brecht Van Berkel2

  • 1UZ Leuven, Herestraat 49, 3000 Leuven, Belgium.

Journal of the Belgian Society of Radiology
|June 10, 2024
PubMed
Summary
This summary is machine-generated.

Twiddler's syndrome is a rare complication after neurostimulator or pacemaker implantation. It occurs when the generator twists, causing electrode dislodgement or interruption, which is detectable on X-ray.

Keywords:
Twiddler’s syndromedeep brain stimulationultrasoundx-ray

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Area of Science:

  • Medical Devices
  • Neurosurgery
  • Radiology

Background:

  • Twiddler's syndrome is a rare but severe complication following the implantation of neurostimulators or pacemakers.
  • It arises from the mechanical manipulation of the implanted generator within its subcutaneous pocket.

Purpose of the Study:

  • To highlight the etiology and radiographic findings of Twiddler's syndrome.
  • To emphasize the importance of recognizing this complication for appropriate patient management.

Main Methods:

  • Review of clinical cases and radiographic findings associated with Twiddler's syndrome.
  • Analysis of the mechanism of generator migration and electrode disruption.

Main Results:

  • Twiddler's syndrome involves the twisting of the generator, leading to lead dislodgement or malfunction.
  • Radiographic examination is crucial for diagnosing the dislodged electrodes and abnormal generator position.

Conclusions:

  • Twiddler's syndrome is a preventable complication that requires awareness among implanting physicians.
  • Early diagnosis via X-ray is essential for timely intervention and to prevent further complications.