Multi-Organ Systems Involvement in COVID-19 is Associated With a Worse Prognosis

Area of Science:

• Internal Medicine
• Infectious Diseases
• Critical Care Medicine

Background:

• Coronavirus disease 2019 (COVID-19) is known to affect multiple organ systems.
• The relationship between the extent of organ system involvement and COVID-19 prognosis remains under-investigated.

Purpose of the Study:

• To investigate the association between the number of organ systems involved in COVID-19 and in-hospital mortality.
• To examine the association between organ system involvement and hospital length of stay (LOS) in COVID-19 patients.

Main Methods:

• A retrospective study was conducted on 808 consecutive patients diagnosed with COVID-19.
• Data were collected from patients admitted to a New York hospital between March 1 and May 15, 2020.

Main Results:

• An increased number of affected organ systems was significantly associated with higher odds of in-hospital mortality (OR: 1.36) and increased LOS.
• Elevated white blood cell count, high FiO2 oxygen requirement, and invasive mechanical ventilation were linked to increased mortality.
• Increased creatinine and glucose levels correlated with longer LOS.

Conclusions:

• Multiple organ system involvement in COVID-19 is a significant indicator of a worse prognosis.
• Clinical and laboratory parameters reflecting organ system involvement can serve as valuable prognostic tools for guiding COVID-19 patient treatment strategies.