Megahertz multi-parametric ophthalmic OCT system for whole eye imaging.

Area of Science:

• Ophthalmic imaging
• Biomedical optics
• Medical instrumentation

Background:

• Comprehensive ocular parameters and pathology quantification require advanced imaging systems.
• Existing optical coherence tomography (OCT) systems face limitations in speed and field of view for complete ocular assessment.

Purpose of the Study:

• To develop and validate a multi-parametric ophthalmic OCT system capable of ultrahigh-speed, wide-field imaging for both anterior and posterior ocular segments.
• To enhance the accuracy and efficiency of ocular biometric measurements and pathology size quantification.

Main Methods:

• Development of a multi-parametric ophthalmic OCT system operating at 1 MHz for retinal imaging and 50 kHz for anterior segment and biometric measurements.
• Implementation of a spectrum correction algorithm to improve A-scan speed and adjacent A-line pairing.
• Introduction of a position feedback-based registration method to minimize galvanometer scanning offsets.
• Proposal of a revised formula for true fundus size determination using multi-field axial length parameters.

Main Results:

• The developed OCT system achieved 1 MHz speed for wide-field retinal imaging and 50 kHz for anterior segment and ocular biometry.
• The spectrum correction algorithm successfully increased A-scan speed, and the registration method reduced pixel offsets by 2.3 times.
• Experimental validation on glass sheets and human eyes confirmed the system's feasibility and efficacy.
• The revised formula provided accurate "true" fundus size determination.

Conclusions:

• The ultrahigh-speed, multi-parametric ophthalmic OCT system demonstrates significant advancements in ocular imaging speed and accuracy.
• The implemented algorithms and system design show strong potential for clinical integration and commercialization, improving ophthalmic diagnostics.