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Updated: Jun 24, 2025

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Qualitative Identification of Carboxylic Acids, Boronic Acids, and Amines Using Cruciform Fluorophores
Published on: August 19, 2013
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Development of a fluorous trapping reagent for rapid detection of electrophilic reactive metabolites
Yusuke Akagi1,2, Hiroyuki Yamakoshi1, Yoshiharu Iwabuchi1
1Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Japan. y-iwabuchi@tohoku.ac.jp.
Analytical Methods : Advancing Methods and Applications
|June 10, 2024
Abstract:
A cysteine-based fluorous trapping reagent, Rf8CYS, was developed. Rf8CYS formed adducts with soft and hard electrophilic reactive metabolites. These fluorous-tagged adducts were purified via both fluorous solid-phase extraction and the direct injection method. The highly sensitive mass spectrometric detection of an unprecedented adduct of the ticlopidine metabolite was realized.

