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Oxidative Generation of Isobenzofurans for Intermolecular Cycloadditions.

Emi Nakatsugawa1, Keigetsu Higashiyama1, Hiroyuki Yamakoshi1

  • 1Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.

The Journal of Organic Chemistry
|November 18, 2025
PubMed
Summary

Phthalans undergo tandem oxidation and Diels-Alder reactions to form oxygen-bridged polycycles. This efficient synthesis uses 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and manganese(III) acetate for catalytic oxidation.

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