Related Experiment Video
Updated: Jun 24, 2025
07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
11.4K
Aspergillus terreus panophthalmitis with orbital cellulitis
Manu Saini1, Usha Singh1, Shivaprakash Mandya Rudramurthy2
1Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Summary
A rare case of Aspergillus terreus caused severe eye infection (panophthalmitis) in a healthy adolescent. Prompt treatment with voriconazole was crucial for recovery.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Mycology
Background:
- Panophthalmitis and orbital cellulitis are severe ocular infections.
- Fungal infections can present with atypical antimicrobial susceptibility.
Observation:
- An 11-year-old male presented with unilateral eye pain, redness, and vision loss.
- Initial antibiotic treatment failed, and the condition worsened, suggesting a fungal cause.
- Ocular deterioration occurred despite amphotericin B, indicating a fastidious pathogen.
Findings:
- Aspergillus terreus was identified in vitreous fluid.
- The infection responded effectively to intravenous voriconazole.
- This case highlights a unique antimicrobial susceptibility profile for Aspergillus terreus.
Implications:
- Aspergillus terreus can cause severe panophthalmitis and orbital cellulitis in immunocompetent adolescents.
- Early diagnosis and targeted antifungal therapy are critical for favorable outcomes.
- This case expands the understanding of fungal keratitis presentations in young individuals.
Related Concept Videos
01:25Glaucoma: Overview
541
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
541
01:28Angle Closure Glaucoma: Treatment
473
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
473