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Modelling the controlled drug release of push-pull osmotic pump tablets using DEM
Jiawei Hu1, Ling Zhang1, Wen Li2
1School of Chemistry and Chemical Engineering, University of Surrey, Guildford, UK.
International Journal of Pharmaceutics
|June 10, 2024
Summary
This study models push-pull osmotic pump tablet drug release using discrete element method (DEM). Key factors influencing drug release rate include orifice size, swellable particle content, and formulation properties like friction and cohesion.
Area of Science:
- Pharmaceutical Sciences
- Computational Modeling
- Materials Science
Background:
- Push-pull osmotic pump tablets offer advanced drug delivery with predictable release rates.
- Traditional dosage forms often lack precise control over drug release kinetics.
Purpose of the Study:
- To model the drug release process in push-pull osmotic pump tablets using the discrete element method (DEM).
- To analyze the impact of formulation design and dosage parameters on drug release performance.
Main Methods:
- Utilized the discrete element method (DEM) integrated with a microscopic diffusion-induced swelling model.
- Systematically investigated effects of delivery orifice size, drug-to-polymer ratio, tablet surface curvature, inter-particle friction, and polymer cohesion.
Main Results:
- Enlarged delivery orifice significantly enhances total drug release and release rate.
- Increased swellable particle content elevates the drug release rate.
- Tablet surface curvature positively correlates with final drug release percentage.
- Drug release rate is controllable via inter-particle friction and polymer particle cohesion.
Conclusions:
- DEM modeling provides valuable insights into push-pull osmotic pump tablet drug release mechanisms.
- Formulation and design parameters critically influence drug release kinetics.
- This approach enables optimization of osmotic pump tablet performance for enhanced drug delivery.
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