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EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Jun 24, 2025

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

Human-mouse chimeric brain models constructed from iPSC-derived brain cells: Applications and challenges.

Ya Zhao¹, Ke Liu², Yinghua Wang³

¹Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi 710032, PR China.

Experimental Neurology

|June 10, 2024

Summary

Human induced pluripotent stem cells (iPSCs) are used to create chimeric brain models for studying brain disorders. These models aid in understanding disease mechanisms and developing new cell transplantation therapies.

Keywords:

Brain cells Chimeric mouse model Differentiate Function Human induced pluripotent stem cell Integration

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Last Updated: Jun 24, 2025

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Published on: April 14, 2017

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A Human Cerebral Organoid Model of Neural Cell Transplantation

A Human Cerebral Organoid Model of Neural Cell Transplantation

Published on: July 21, 2023

Area of Science:

Neuroscience
Stem Cell Biology
Regenerative Medicine

Background:

Reliable human brain models are crucial for understanding brain disorders and developing treatments.
Human induced pluripotent stem cells (iPSCs) offer a versatile source for generating specialized brain cells.
Human-mouse chimeric brain models are emerging as powerful tools for disease modeling and therapeutic exploration.

Purpose of the Study:

To review advancements in differentiating human iPSCs into specialized brain cells.
To evaluate the characteristics and functions of human-mouse chimeric brain models.
To highlight the potential of these models for reconstructing neural circuitry and assessing cell integration.

Main Methods:

Review of recent literature on human iPSC differentiation protocols for brain cells.
Analysis of studies utilizing human-mouse chimeric brain models for disease modeling.
Evaluation of factors influencing in vivo integration and differentiation of transplanted iPSC-derived cells.

Main Results:

Significant progress has been made in generating diverse, specialized human brain cells from iPSCs.
Human-mouse chimeric brain models demonstrate potential for in vivo neural circuitry reconstruction.
Factors influencing the integration and differentiation of grafted iPSC-derived cells have been identified.

Conclusions:

Human iPSC-derived brain cells and chimeric models offer promising avenues for studying neuropsychiatric disorders, infectious diseases, and brain injuries.
These models are valuable for advancing cell transplantation therapies and related clinical research.
Further research into iPSC differentiation and chimeric model development will accelerate therapeutic discoveries for brain disorders.