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A Method for the Determination of Rate Coefficients for the Formation of Protonated Monomers and Proton Bound Dimers of Volatile Organic Compounds in Air at Ambient Pressure by Ion Mobility Spectrometry.

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Time-Resolved Ion Mobility Spectrometry with a Stop Flow Confined Volume Reaction Region.

Osmo Anttalainen¹, Markus Karjalainen¹, Elie Lattouf¹

¹VERIFIN, Finnish Institute for Verification of the Chemical Weapons Convention, Department of Chemistry, University of Helsinki, Helsinki FI-00014, Finland.

Analytical Chemistry

|June 10, 2024

Summary

This summary is machine-generated.

A novel stopped-flow technique in ion mobility spectrometry separates volatile organic compounds based on ion reaction kinetics, improving signal-to-noise for enhanced analysis.

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Area of Science:

Analytical Chemistry
Physical Chemistry

Background:

Ion mobility spectrometry (IMS) is a powerful analytical technique for separating ions.
Conventional IMS often relies on continuous gas flow, which can limit separation efficiency for complex mixtures.

Purpose of the Study:

To introduce and evaluate a novel stopped-flow ion source concept for ion mobility spectrometry.
To demonstrate the potential for temporal separation of volatile organic compounds (VOCs) based on ion kinetics.

Main Methods:

A stopped-flow technique was implemented in a confined volume within an ion mobility spectrometer.
Hydrated protons were used as primary ions, generated via corona discharge.
Time-dependent ion signal intensities were measured and analyzed using mobility spectra.

Main Results:

The stopped-flow method created time-dependent ion signal patterns for VOC mixtures.
Distinct times of appearance for protonated monomers and dimers were observed, extending over 30 seconds.
Improved signal-to-noise rates were achieved compared to conventional drift gas flow.

Conclusions:

The stopped-flow technique enables temporal separation of atmospheric pressure ions based on ion kinetics.
This method offers a new approach for analyzing VOCs without requiring chromatographic separation.
The observed separation is attributed to differences in ion reaction rates and cross-reactions.