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Updated: Jun 24, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Effectiveness of Lidocaine Infusion Versus Valproate Infusion for Pediatric Status Migrainosus

Marco Antonio Ayulo1, Sharaya Jenkins2, Thanh Le3

  • 1Divisions of Pediatric Critical Care Medicine.

Hospital Pediatrics
|June 11, 2024
PubMed

Insights

Intravenous lidocaine infusion offers faster pain relief and a better safety profile for pediatric status migrainosus compared to sodium valproate. This study highlights lidocaine as a potentially superior treatment option for children experiencing severe migraine attacks.

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Pharmacology

Background:

  • Status migrainosus is a debilitating condition in children and adolescents.
  • Current treatment options for pediatric status migrainosus have varying efficacy and safety profiles.

Purpose of the Study:

  • To compare the efficacy and safety of intravenous lidocaine infusion versus sodium valproate infusion for treating pediatric status migrainosus.

Main Methods:

  • A retrospective cohort study analyzed 94 pediatric patients with status migrainosus treated with either lidocaine or sodium valproate infusion.
  • Data collected included time to pain resolution, pain-free status at discharge, infusion interruptions, and adverse effects.

Main Results:

  • Lidocaine infusion resulted in significantly faster pain control (median 11.7 hours vs. 43.4 hours) and higher pain-free rates at discharge (67.7% vs. 44.1%) compared to valproate.
  • Valproate infusions had more interruptions (25.4% vs. 3.2%) and a higher incidence of adverse effects (67% vs. 3.2%) than lidocaine.

Conclusions:

  • Intravenous lidocaine infusion demonstrates superior efficacy in pain control and a better safety profile for pediatric status migrainosus when compared to sodium valproate infusion.
  • Lidocaine should be considered a preferred treatment option for managing severe migraine attacks in pediatric patients.
Abstract

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