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Updated: Jun 24, 2025
Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Multicomponent Carbonylation of Halides to Acylhydrazones
Qianqian Liang1,2, Shuo Gao1,2, Wentao Hao1,2
1State Key Laboratory of Coal Conversion, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan 030001, China.
Abstract:
The current methods for synthesizing acylhydrazones are limited by their multistep processes, narrow substrate scope, low selectivities, and poor yields. Herein, a fundamentally novel approach to bioactive acylhydrazones was developed based on the palladium-catalyzed multicomponent tandem condensation carbonylation of halides with aldehydes and hydrazines. This method provides a useful and efficient strategy for generating grams of various acylhydrazones in a one-pot manner. Mechanistic studies provided evidence of facile carbonylation of halides with the weak nucleophile hydrazones facilitated by a base.
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