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Mapping myeloid cell function: Spatial diversity in tumor and neuronal microenvironment
Giulia Villa1, Daniel Delev2, Dieter Henrik Heiland3
1Department of Translational Neurosurgery, Alexander-Friedrich-Universität Erlangen-Nürnberg, Erlangen, Germany.
Cancer Cell
|June 11, 2024
Abstract:
In this issue of Cancer Cell, Zhong et al. explore the dual role of TREM2 in glioblastoma-associated myeloid cells, demonstrating its function in promoting inflammation at the tumor-neural interface and suppression within the tumor core, influenced by the local microenvironment. These findings open up promising prospects for advancements in neuro-oncological immunotherapy.

