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Author Spotlight: Investigating Liver Cancer Pathogenesis Using Patient-Derived Organoids

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Liver-based inter-organ communication: A disease perspective.

Xin-Yan Luo¹, Si-Qi Ying², Yuan Cao³

¹State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China; School of Basic Medicine, The Fourth Military Medical University, Xi'an 710032, China.

|June 11, 2024

Summary

The liver communicates with distant organs like the brain and gut via extracellular vesicles (EVs) and hepatokines. Understanding this crosstalk is key for diagnosing and treating liver diseases.

Keywords:

Extracellular vesicles Hepatokines Inter-organ communication Liver Theranostics

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Area of Science:

Endocrinology
Molecular Biology
Physiology

Background:

Inter-organ communication is vital for maintaining homeostasis and energy utilization.
The liver plays a central role in coordinating multiple tissues and organs.
Liver-derived extracellular vesicles (EVs) and hepatokines are emerging as key mediators of this communication.

Purpose of the Study:

To review the crosstalk between the liver and distant organs.
To highlight the roles of EVs and hepatokines in liver-mediated communication.
To explore the implications for diagnosing and treating liver-related diseases.

Main Methods:

Literature review of studies on liver-organ communication.
Focus on mechanisms involving extracellular vesicles (EVs).
Analysis of hepatokine secretion and function.

Main Results:

The liver communicates with the brain, bone, adipose tissue, and intestine.
Liver-derived EVs and hepatokines are critical in regulating physiological and pathological processes.
This communication network influences organismal homeostasis.

Conclusions:

Investigating liver-centric multi-organ communication, particularly via EVs and hepatokines, is crucial.
Understanding these pathways offers new dimensions for organismal homeostasis.
This knowledge can lead to novel theranostics for pathologies.