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Related Experiment Video

Updated: Jun 24, 2025

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Published on: October 13, 2023

[Study on Circulating Tumor Cell Detection System Based on Microfluidic Chip].

Yuanshuai Di¹, Ji Luo¹, Dadi Gao¹

¹Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032.

Zhongguo Yi Liao Qi Xie Za Zhi = Chinese Journal of Medical Instrumentation

|June 12, 2024

Summary

This summary is machine-generated.

This study presents a microfluidic chip for high-throughput detection of circulating tumor cells (CTCs). The system achieves a high detection rate, offering reliable early cancer screening.

Keywords:

circulating tumor cells early screening fluorescence detection microfluidic chip sorting and enrichment

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Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

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Last Updated: Jun 24, 2025

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Published on: October 13, 2023

Capture and Release of Viable Circulating Tumor Cells from Blood

Capture and Release of Viable Circulating Tumor Cells from Blood

Published on: October 28, 2016

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

Area of Science:

Biomedical Engineering
Oncology
Microfluidics

Context:

Circulating tumor cells (CTCs) are crucial biomarkers for cancer detection and monitoring.
Current methods for CTC detection face challenges in throughput and sensitivity.
Early cancer screening is vital for improving patient outcomes.

Purpose:

To develop and validate a microfluidic chip for efficient sorting, enrichment, and detection of CTCs.
To achieve high throughput and a high detection rate for CTCs in peripheral blood.
To enable accurate, single-cell level detection of CTCs for early cancer screening.

Summary:

A novel microfluidic chip integrating sorting, enrichment, and detection capabilities was designed.
CTCs were detected at the single-cell level using a fluorescence detection system.
The system achieved a maximum CTC detection rate of 78.6% at an injection rate of 0.2 mL/h, with a correlation coefficient above 0.8.

Impact:

The developed CTCs detection system demonstrates high reliability and detection rates.
This technology can serve as a valuable tool for clinical research in cancer diagnostics.
Provides a foundation for improved early cancer detection and patient management strategies.