Field Study and Correlative Studies of Factor IX Variant FIX-R338L in Participants Treated with Fidanacogene

Debra D Pittman1, Charles Carrieri2, Holly Soares2

  • 1Rare Disease Research Unit, Pfizer Inc., Cambridge, Massachusetts, United States.

PubMed
Abstract

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Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...