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Hide-and-Seek With Spindle-Cell-Component-Poor Metaplastic Thymoma.

Gintarė Ražanskienė1, Vilhelmas Landsbergis2, Vytenis Bertašius3,2

  • 1National Center of Pathology, Vilnius University Hospital Santaros Klinikos, Vilnius, LTU.

Cureus
|June 12, 2024
PubMed
Summary

Metaplastic thymoma, a rare indolent tumor, can mimic type A thymoma due to sparse spindle cells. This case highlights diagnostic clues and presents the first association with psoriasis.

Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Metaplastic thymoma is a rare thymic neoplasm characterized by biphasic histology and indolent behavior.
Keywords:
islet-1metaplastic thymomaparaneoplastic syndromepsoriasisyap1::maml2

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  • A recurrent YAP1::MAML2 gene rearrangement is a hallmark of metaplastic thymoma.
  • Diagnostic challenges arise when metaplastic thymoma exhibits scant spindle-cell components, resembling type A thymoma.