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Updated: Jun 24, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium/Amine Dual-Catalyzed Tsuji-Trost Fluoroallylation of Aldehydes with gem-Difluorinated Cyclopropanes
Zheng Su1, Binhong Tan1, Zhaodong Li1
1College of Materials and Energy, South China Agricultural University, 510642 Guangzhou, China.
Abstract:
We herein disclose the Pd/amine dual-catalyzed ring-opening cross-coupling reaction between gem-difluorinated cyclopropanes (gem-F2CPs) with aldehydes, which enables the diversity-oriented synthesis (DOS) of 2-fluoroallylic aldehydes bearing all-carbon quaternary centers with features of broad scope and excellent functional group tolerance. The synthetic value of this Tsuji-Trost system was further demonstrated by late-stage functionalization of natural product-derived gem-F2CPs and the diverse synthesis of various fluoroallylic aldehyde derivatives, including alcohol, alkyne, alkene, and amine.
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