Metal-organic frameworks for biomedical applications: A review.

Area of Science:

• Materials Science
• Biomedical Engineering
• Nanotechnology

Background:

• Metal-organic frameworks (MOFs) are advanced porous materials with tunable properties.
• Their unique characteristics, including high surface area and defined active sites, make them promising for biomedical applications.
• MOFs offer potential for developing novel diagnostic and therapeutic tools.

Purpose of the Study:

• To review recent advancements in MOF applications within the biomedical field.
• To explore the design, preparation, and properties of MOFs for biosensing and therapy.
• To discuss current challenges and future perspectives for MOF-based biomedical technologies.

Main Methods:

• Literature review of MOF synthesis and characterization for biomedical applications.
• Analysis of MOF properties relevant to biosensing, imaging, and therapy.
• Compilation of studies on MOF-based diagnostic and therapeutic systems.

Main Results:

• MOFs show significant potential for real-time biomolecule sensing and point-of-care diagnostics.
• Their enzyme-mimicking capabilities and biocompatibility are key for therapeutic applications.
• MOFs are being explored for advanced imaging and photodynamic therapy.

Conclusions:

• MOFs represent a versatile platform for diverse biomedical applications, from sensing to therapy.
• Further research is needed to overcome challenges and translate MOF technologies from proof-of-concept to clinical use.
• Interdisciplinary collaboration is crucial for advancing MOF applications in biomedicine.