Related Experiment Video

Updated: Jun 24, 2025

Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses
06:13

Handling of the Cotton Rat in Studies for the Pre-clinical Evaluation of Oncolytic Viruses

Published on: November 24, 2014

9.3K

A comparative review of adenovirus A12 and C5 oncogenes

Luca D Bertzbach1, Wing-Hang Ip1, Konstantin von Stromberg1

  • 1Department of Viral Transformation, Leibniz Institute of Virology (LIV), Martinistraße 52, 20251 Hamburg, Germany.

Current Opinion in Virology
|June 12, 2024
PubMed

Insights

Oncogenic viruses, like human adenoviruses (HAdVs), drive cancer by altering cell pathways. Understanding HAdV-A12 and HAdV-C5 oncoproteins is key to viral oncogenesis research.

Area of Science:

  • Virology
  • Oncology
  • Molecular Biology

Background:

  • Oncogenic viruses are responsible for a significant portion of human cancers.
  • Adenoviruses were the first human viruses demonstrated to induce cancer in animal models.
  • Human adenovirus (HAdV)-mediated oncogenic transformation is crucial for understanding cancer development.

Purpose of the Study:

  • To elucidate the distinct roles of HAdV-A12 and HAdV-C5 oncoproteins in viral oncogenesis.
  • To provide a comprehensive understanding of adenovirus-mediated cell transformation.
  • To offer broader insights into viral transformation and oncogenesis.

Main Methods:

  • Review and summarization of existing research on adenovirus oncoproteins.
  • Analysis of molecular mechanisms underlying HAdV-mediated cell transformation.
  • Comparative study of HAdV-A12 and HAdV-C5 oncogenic potential.

Main Results:

  • Adenovirus oncoproteins, particularly those encoded by early regions 1 (E1) and 4 (E4), deregulate cellular transcription and antagonize cellular pathways.
  • HAdV-A12 exhibits higher oncogenicity compared to the extensively studied HAdV-C5.
  • Distinct molecular mechanisms contribute to the oncogenic transformation capabilities of different HAdV species.

Conclusions:

  • A thorough understanding of HAdV-A12 and HAdV-C5 oncoproteins is essential for advancing adenovirus research.
  • Insights into viral transformation and oncogenesis are enhanced by studying these oncoproteins.
  • This knowledge is relevant for developing strategies against virus-induced cancers.

More Related Videos

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

10.4K
Author Spotlight: Unveiling the Potential of Unpurified Recombinant AAVs in Cell Culture Research06:41

Author Spotlight: Unveiling the Potential of Unpurified Recombinant AAVs in Cell Culture Research

Published on: October 20, 2023

2.9K

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.1K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.8K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K