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Updated: Jun 24, 2025
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Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo
Published on: October 11, 2022
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Claudin 18 turns up the heat in cancer
Jialin Zhang1, Peter M K Westcott1
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
Immunity
|June 12, 2024
Abstract:
A major barrier to antitumor immunity in solid tumors is T cell exclusion. In this issue of Immunity, De Sanctis et al.1 elucidate how CLDN18 on pancreatic and lung cancer cells enhances infiltration, immunological synapse formation, and activation of cytotoxic T lymphocytes.
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