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Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Endoscopic Procedures II: Colonoscopy01:25

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The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
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Disorders of Hemostasis01:24

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
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Esophageal Varices-II: Clinical Features and Management01:28

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Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
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Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

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Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
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Updated: Jun 24, 2025

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
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Anticoagulants Are a Risk Factor for Delayed Bleeding after Colorectal Endoscopic Submucosal Dissection: A HASID

Seong-Jung Kim1, Jun Lee1, Hyo-Yeop Song2

  • 1Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Republic of Korea.

Digestion
|June 12, 2024
PubMed
Summary
This summary is machine-generated.

Anticoagulant use increases the risk of delayed bleeding after colorectal endoscopic submucosal dissection (ESD). Careful monitoring is essential for patients undergoing colorectal ESD while on anticoagulants.

Keywords:
AnticoagulantsColorectal neoplasmEndoscopic submucosal dissectionHemorrhage

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Area of Science:

  • Gastroenterology
  • Endoscopy
  • Hepatology

Background:

  • Delayed bleeding is a significant complication following colorectal endoscopic submucosal dissection (ESD).
  • The role of anticoagulants as risk factors for this complication remains uncertain.

Purpose of the Study:

  • To investigate the risk factors for delayed bleeding after colorectal ESD.
  • Specifically evaluate the impact of anticoagulant use on delayed bleeding incidence.

Main Methods:

  • Retrospective analysis of 1,708 patients undergoing colorectal ESD from 2015-2020.
  • Identification of risk factors, focusing on antithrombotic agents, antiplatelet agents, and anticoagulants.

Main Results:

  • Delayed bleeding occurred in 2.3% of patients.
  • Antithrombotic agents (OR 6.16), antiplatelet agents (OR 4.61), and anticoagulants (OR 8.29) were significant risk factors.
  • Anticoagulant use was associated with a higher delayed bleeding rate (12.5% vs. 1.6%) when antiplatelet agents were excluded.

Conclusions:

  • Anticoagulant use is a significant risk factor for delayed bleeding post-colorectal ESD.
  • The type of anticoagulant (direct oral anticoagulants vs. warfarin) did not influence the risk.
  • Patients on anticoagulants require vigilant observation and management for delayed bleeding after colorectal ESD.