Editorial Commentary: Three-Dimensional-Printed Biphasic (Osteochondral) Scaffolds Delivering Autologous Chondrocytes...

Three-dimensional-printed biphasic scaffolds combine autologous chondrocytes for effective cartilage repair. A recent study demonstrated promising short-term outcomes for biphasic scaffolds compared with traditional marrow-stimulation techniques, although long-term durability and appropriate control comparisons remain concerns. Scaffold materials can include polysaccharides (e.g., alginate, hyaluronic acid, and chitosan) and proteins (e.g., collagen, gelatin, and fibronectin). They also may be combined with other classes of materials to improve their mechanical properties and bioactivity. Synthetic polymers include polyethylene glycol and poly(lactic-co-glycolic acid), among many others. Challenges of these scaffold materials include biocompatibility, inadequate integration, and variability in clinical outcomes. Delivering autologous minced chondrocytes via a biphasic scaffold consisting of poly(lactic-co-glycolic acid) for the chondral phase and β-tricalcium phosphate for the osseous phase is a promising technology.