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The Role of Coagulation in Heart Failure: A Literature Review

Farhan Anjum1, Mahrukh Gilani2, Maryam Latif1

  • 1Institute of Zoology, University of Punjab, Quaid-I-Azam Campus, Lahore, Pakistan.

Current Heart Failure Reports
|June 13, 2024
PubMed

Insights

Coagulation factors like D-dimer and fibrinogen are key in heart failure pathophysiology. Understanding these roles aids in diagnosing and treating heart failure effectively.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biochemistry

Background:

  • Heart failure (HF) involves complex pathophysiological mechanisms.
  • Coagulation system dysregulation is increasingly recognized in HF.

Purpose of the Study:

  • To review the role of various coagulation factors in heart failure pathophysiology.
  • To explore their diagnostic, prognostic, and therapeutic implications.

Main Methods:

  • Literature review of studies investigating coagulation factors in heart failure.
  • Analysis of associations between specific factors and HF pathology.

Main Results:

  • D-dimer, P-selectin, prothrombin, von Willebrand factor, tissue plasminogen activator, fibrinogen, suPAR, tissue factor, thrombomodulin, and Factor XI are significantly involved in HF pathophysiology.
  • No associations were found for β-thromboglobulin, tissue thromboplastin, PAI-1, and stuart-prower factor in HF.
  • Coagulation factor changes are linked to HF diagnosis, prognosis, and treatment.

Conclusions:

  • Specific coagulation factors play crucial roles in the development and progression of heart failure.
  • Targeting these factors may offer new avenues for heart failure management.
Abstract

Keywords:
Coagulation factorsHeart failurePathophysiology

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