Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Retrovirus Life Cycles01:10

Retrovirus Life Cycles

45.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.8K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

934
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
934
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

299
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
299

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Karyoptosis mediates cell death and neurodegeneration upon proteotoxic stress.

Nature communications·2026
Same author

Infectious Diseases Fellowship Curriculum: IDSA Training Program Directors Community of Practice (TPDCOP), Curricular and Educational REsources Workgroup (CREW).

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Ethical Considerations in the Use of Indwelling Lines in Persons Who Use Injection Drugs.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Treatment Approaches for Refractory <i>Mycoplasma genitalium</i> Infection.

Open forum infectious diseases·2026
Same author

Advancing nutrition education: Harvard medical student reflections on a scalable online course.

The American journal of medicine·2026
Same author

A Blurry Line: Navigating Treatment Decisions When the Guidelines Don't Fit.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same journal

Prevention and Control of Clostridioides difficile Infection for the Infectious Diseases Clinician.

Infectious disease clinics of North America·2026
Same journal

Infection Control Strategies to Prevent Emergence and Transmission of Resistant Gram-Negative Bacteria.

Infectious disease clinics of North America·2026
Same journal

Preventing the Spread of Tuberculosis in Health Care Settings.

Infectious disease clinics of North America·2026
Same journal

Threats to Success: Principles of Infection Prevention and Control in Health Care Settings, Part 2: Device and Pathogen Management.

Infectious disease clinics of North America·2026
Same journal

Ventilator-Associated Events: Surveillance and Prevention.

Infectious disease clinics of North America·2026
Same journal

Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Prevention of Candida and Other Yeasts.

Infectious disease clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.4K

Switching Human Immunodeficiency Virus Therapy: Basic Principles and Options.

Danilo Bacic Lima1, Daniel A Solomon2

  • 1Massachusetts General Hospital and Brigham & Women's Hospital; Infectious Diseases Division, Brigham and Women's Hospital, 75 Francis Street, PBB-A4, Boston, MA 02115, USA. Electronic address: https://twitter.com/danbacic.

Infectious Disease Clinics of North America
|June 13, 2024
PubMed
Summary
This summary is machine-generated.

Newer antiretroviral therapy (ART) options offer improved safety, tolerability, and convenience for HIV treatment. This guide helps clinicians decide when and how to switch patients to more effective ART regimens.

Keywords:
ARTAntiretroviralHIVSwitch

More Related Videos

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

17.8K
Humanized NOD/SCID/IL2r&#947;null (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

15.7K

Related Experiment Videos

Last Updated: Jun 24, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
06:07

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

2.4K
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

17.8K
Humanized NOD/SCID/IL2r&#947;null (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

15.7K

Area of Science:

  • Infectious Diseases
  • Virology
  • Pharmacology

Background:

  • Effective antiretroviral therapy (ART) options for HIV are expanding.
  • While older ART regimens achieve virologic suppression, newer options present enhanced safety, tolerability, and convenience.

Purpose of the Study:

  • To provide guiding principles for switching ART regimens.
  • To highlight reasons for initiating an ART switch.
  • To outline key factors in selecting a new ART regimen.

Main Methods:

  • Literature review of current ART guidelines and clinical trial data.
  • Analysis of safety, tolerability, and convenience profiles of various ART regimens.
  • Development of a decision-making framework for ART regimen selection.

Main Results:

  • Identification of specific clinical scenarios warranting an ART switch.
  • Evaluation of newer ART options based on efficacy, safety, and patient-centered outcomes.
  • Consideration of drug interactions, comorbidities, and patient adherence in regimen selection.

Conclusions:

  • Switching ART can optimize treatment outcomes by leveraging newer, more advantageous regimens.
  • A systematic approach to ART selection ensures improved patient safety, tolerability, and convenience.
  • Personalized ART strategies are crucial for long-term HIV management and virologic suppression.