Related Experiment Video
Updated: Jun 24, 2025
06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
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Circadian clock gene polymorphisms implicated in human pathologies.
Jesse R Janoski1, Ignacio Aiello2, Clayton W Lundberg3
1Integrated Cellular Responses Laboratory, Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.
Trends in Genetics : TIG
|June 13, 2024
Summary
Circadian rhythms, regulated by core clock genes, impact health when dysregulated. Genetic variations in these genes are linked to various health conditions, necessitating further research.
Area of Science:
- Chronobiology
- Genetics
- Molecular Biology
Background:
- Circadian rhythms are endogenous ~24-hour cycles crucial for physiological and behavioral processes.
- These rhythms are synchronized by external cues like light but persist internally.
- Dysregulation of circadian rhythms negatively impacts organismal well-being.
Purpose of the Study:
- To review the role of genetic variations in core clock genes.
- To explore the association between these genetic variations and various phenotypes.
- To highlight the implications for human health and identify research gaps.
Main Methods:
- Review of genome-wide association studies (GWAS).
- Analysis of forward genetic studies.
- Examination of genetic variations in core clock genes.
Main Results:
- Single Nucleotide Polymorphisms (SNPs) in clock genes affect gene regulation.
- These genetic variations correlate with the risk of developing various conditions.
- Specific genetic variations are associated with distinct phenotypes.
Conclusions:
- Genetic variations in core clock genes have significant implications for human health.
- Understanding these variations is crucial for addressing circadian rhythm-related disorders.
- Further comprehensive studies are needed in the field of circadian genetics.
Keywords:
circadian medicinecircadian rhythmclock genesgenetic variationsgenome-wide associationpolymorphismMore Related Videos
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