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Updated: Jun 24, 2025

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
Published on: January 11, 2020
Sulfur fluoride exchange
Joshua A Homer1, Long Xu2,3, Namitharan Kayambu4
1Cancer Center, Cold Spring Harbor Laboratory, 1 Bungtown Road, NY 11724, USA.
Abstract:
Sulfur Fluoride Exchange (SuFEx) is a click reaction par excellence that has revolutionized multiple research fields. In this Primer, we delve into the essential elements of SuFEx operation, catalysis, and SuFExable connective hubs. We also explore the cutting-edge applications of SuFEx in drug development, polymer science, and biochemistry. Additionally, we examine the potential limitations and promising prospects for this versatile click reaction.
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