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18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography

Published on: January 11, 2020

Sulfur fluoride exchange.

Joshua A Homer¹, Long Xu^2,3, Namitharan Kayambu⁴

¹Cancer Center, Cold Spring Harbor Laboratory, 1 Bungtown Road, NY 11724, USA.

Nature Reviews. Methods Primers

|June 14, 2024

Summary

This summary is machine-generated.

Sulfur Fluoride Exchange (SuFEx) is a powerful click reaction transforming various scientific fields. This primer explores its mechanisms, applications in drug development and polymer science, and future potential.

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Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB

Published on: June 28, 2011

Area of Science:

Chemical Biology
Polymer Science
Medicinal Chemistry

Background:

Sulfur Fluoride Exchange (SuFEx) has emerged as a highly efficient click reaction.
Its versatility has led to significant advancements across multiple scientific disciplines.

Purpose of the Study:

To provide a comprehensive overview of Sulfur Fluoride Exchange (SuFEx) click chemistry.
To detail the operational principles, catalysis, and key components of SuFEx reactions.
To highlight the diverse applications and future directions of SuFEx.

Main Methods:

Review of fundamental SuFEx reaction mechanisms.
Exploration of catalytic systems enabling SuFEx transformations.
Analysis of SuFExable connective hubs and their roles.
Case studies of SuFEx applications in drug discovery, polymer synthesis, and biochemistry.

Main Results:

SuFEx reactions are characterized by high efficiency, selectivity, and mild reaction conditions.
SuFEx has enabled the development of novel polymers and complex biomolecules.
Key applications include bioconjugation, materials science, and pharmaceutical development.

Conclusions:

SuFEx represents a powerful and versatile tool in modern synthetic chemistry.
Its continued development promises further innovation in drug design, materials science, and beyond.
Understanding SuFEx principles is crucial for leveraging its full potential in research and development.