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Baochan Yang1,2,3, Lingzhi Cao4, Kun Ge4

  • 1Beijing Advanced Innovation Center for Materials Genome Engineering, Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, China.

Small (Weinheim an Der Bergstrasse, Germany)
|June 14, 2024
PubMed
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This summary is machine-generated.

New nanozymes control reactive oxygen species (ROS) generation for enhanced cancer immunotherapy. These nanozymes effectively inhibit primary tumors and completely prevent lung metastasis by inducing sequential cancer cell death and immune responses.

Area of Science:

  • Nanomaterials Science
  • Cancer Biology
  • Immunotherapy

Context:

  • Combining nanozymes with immune checkpoint blockade (ICB) therapy faces challenges in controllable reactive oxygen species (ROS) generation for effective immunogenicity.
  • Developing strategies for precise ROS production is crucial for enhancing cancer treatment efficacy and overcoming metastasis.

Purpose:

  • To develop novel nanozymes capable of light-controlled ROS production for synergistic cancer treatment and metastasis inhibition.
  • To investigate the dual-modal therapeutic effects of nanozymes under dark and near-infrared (NIR-II) light irradiation.

Summary:

  • Novel Fe single atom on iridium metallene nanozymes (FeSA-Ir@PF NSs) were synthesized, exhibiting controlled ROS generation via Fenton-like catalysis and photocatalysis.
  • In dark conditions, FeSA-Ir@PF NSs induced ferroptosis and apoptosis; under NIR-II light, they enhanced ROS production, generated singlet oxygen, and induced pyroptosis, achieving 99.1% primary tumor inhibition.
Keywords:
Fe single atom/iridium metallene nanozymecancer lung metastasis inhibitionenhance immunogenicitylight‐controlled ROS productionlight‐controlled ferroptosis/pyroptosis switching

Related Experiment Videos

  • Complete inhibition of lung metastasis was observed in mouse models, including circulating tumor cells (CTCs), when FeSA-Ir@PF NSs were combined with ICB therapy.

    • Impact:

    • This study provides a new platform for developing advanced nanozymes for effective cancer therapy and metastasis control.
    • The findings offer novel insights into light-triggered synergistic treatments combining ROS generation, multiple cell death pathways, and immunotherapy.
    • Demonstrates complete inhibition of cancer lung metastasis, presenting a significant advancement in overcoming metastatic disease.