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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

233
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
233

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Multifunctional Microneedle Patch with Diphlorethohydroxycarmalol for Potential Wound Dressing.

Tae-Hee Kim1,2, Min-Sung Kim3, Nam-Gyun Kim2,4

  • 1Research Center for Marine-Integrated Bionics Technology, Pukyong National University, Busan, 48513, Republic of Korea.

Tissue Engineering and Regenerative Medicine
|June 14, 2024
PubMed
Summary
This summary is machine-generated.

New microneedle (MN) patches containing diphlorethohydroxycarmalol (DPHC) show promise for wound healing. These advanced wound dressings offer antibacterial and anti-inflammatory benefits, effectively treating skin wounds and promoting tissue engineering.

Keywords:
Anti-bacterial activityAnti-inflammatoryDiphlorethohydroxycarmalolMicroneedle patchPolyvinyl alcohol

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Area of Science:

  • Biomaterials Science
  • Dermatology
  • Pharmacology

Background:

  • Current wound healing methods lack specificity and efficacy for diverse wound types.
  • Microneedle (MN) patches integrating bioactive compounds offer a promising advanced wound dressing strategy.
  • Incorporating antibacterial and anti-inflammatory agents into MN patches can enhance wound repair.

Purpose of the Study:

  • To isolate diphlorethohydroxycarmalol (DPHC) from Ishige okamurae and evaluate its anti-inflammatory and antibacterial properties.
  • To fabricate polylactic acid (PLA) microneedle (MN) patches containing DPHC (PDPHC MN patches).
  • To assess the efficacy of PDPHC MN patches in vitro and in vivo for wound healing applications.

Main Methods:

  • DPHC was isolated and its anti-inflammatory effects on macrophages and antibacterial activity against Cutibacterium acnes were assessed.
  • Polylactic acid (PLA) microneedle (MN) patches with varying DPHC concentrations (0-0.3%) were fabricated.
  • Mechanical properties and biological effects of PDPHC MN patches were evaluated using in vitro and in vivo models, including a 2,4-Dinitrochlorobenzene-stimulated mouse model.

Main Results:

  • DPHC demonstrated effective inhibition of nitric oxide production in macrophages and rapid bactericidal activity against C. acnes.
  • The fabricated PDPHC MN patches exhibited potent antibacterial effects without observable cytotoxicity.
  • In vivo studies showed that PDPHC MN patches significantly reduced inflammatory responses and cutaneous lichenification in a mouse model.

Conclusions:

  • The study suggests that PDPHC MN patches possess significant antibacterial and anti-inflammatory properties.
  • These multifunctional microneedle patches show potential as advanced wound dressings for skin tissue engineering.
  • PDPHC MN patches offer a promising approach to promote the wound healing process.