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Melatonin use in infants and toddlers
Judith Owens1, Natalie Barnett2, Maristella Lucchini2
1Boston Children's Hospital, Harvard Medical School, 9 Hope Avenue, Waltham, MA, USA.
Insights
Melatonin use in young children is increasing, but studies show caregivers often get recommendations from non-professionals. This raises concerns about safety and efficacy due to lack of oversight.
Area of Science:
- Pediatric Sleep Medicine
- Pharmacology
Background:
- Melatonin supplements are increasingly used by children in the US.
- There is a lack of data on melatonin's safety and efficacy in children under two years old.
Purpose of the Study:
- To investigate melatonin use in US infants and toddlers.
- To understand caregiver-reported reasons for use and information sources.
Main Methods:
- An online survey was administered to caregivers using the Nanit baby monitoring system.
- Participants had children aged 0-36 months and completed the Brief Infant Sleep Questionnaire-Revised (BISQ-R).
Main Results:
- 1.7% of surveyed caregivers reported using melatonin for their child.
- Half of melatonin users received recommendations from non-healthcare professionals.
- Reasons for use included non-supported indications like improving sleep quality.
Conclusions:
- Widespread pediatric melatonin use warrants concern due to lack of regulation.
- Inaccurate product labeling and non-evidence-based usage highlight safety issues.
Abstract:
Background Melatonin use in the pediatric population is on the rise in the United States, where it is available as an over-the-counter and online supplement. There are no data regarding the safety and efficacy of melatonin in children less than 2 years old. The aim of this study was to examine various aspects of melatonin use by caregivers of infants and toddlers in the US. Methods Caregiver users of the Nanit baby monitoring system with a child aged 0-36 months were invited to complete an online survey regarding melatonin use, sources of information/recommendations about melatonin, formulations used and reasons for administering melatonin to their child. Participants also completed the Brief Infant Sleep Questionnaire-Revised (BISQ-R). Results A total of 3063 caregivers (1.93%) responded to the survey, of whom 1.7% had ever used melatonin for their child. About half of those caregivers had received a recommendation for melatonin from a source other than a healthcare professional. Caregiver perception of 'sleep as a problem' as assessed by the BISQ-R was not significantly different between those who had or had not used melatonin for their child, and reasons for use included non-supported indications such as sleeping later or promoting "more restful and better sleep". Conclusions The results of this study support mounting concerns regarding the widespread use of melatonin in the US pediatric population, especially given the lack of regulatory oversight and the documented inaccuracy of label claims versus actual melatonin content.
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