Role of natural products in cardiovascular disease
Qi Dong1, Gaoying Dai1, Nanhu Quan2
1Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun, 130021, China.
Insights
Aging increases cardiovascular disease (CVD) risk. This review explores molecular pathways, cellular processes, and natural products/dietary habits for preventing and treating age-related CVD.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Molecular Biology
Background:
- Cardiovascular diseases (CVDs) are a leading cause of mortality globally, particularly in aging populations.
- Age-associated CVD mechanisms include oxidative stress, inflammation, and myocardial remodeling.
- Understanding these processes is crucial for developing effective interventions.
Purpose of the Study:
- To review key molecular pathways and cellular processes involved in age-related CVD.
- To explore natural products and dietary habits targeting these mechanisms.
- To provide insights for reducing the cardiovascular burden in aging individuals.
Main Methods:
- Literature review of molecular pathways and cellular processes in aging CVD.
- Analysis of studies on natural products and dietary interventions for cardiovascular health.
- Examination of evidence from animal models and clinical studies.
Main Results:
- Identified key molecular and cellular mechanisms contributing to age-related CVD.
- Highlighted natural products and dietary patterns with potential cardiovascular benefits.
- Synthesized findings from preclinical and clinical research.
Conclusions:
- Natural products and specific dietary habits show promise in managing age-related CVD.
- Further research can elucidate preventive and therapeutic strategies.
- Recommendations can be developed to mitigate cardiovascular risks in the elderly.
Abstract:
As the world's aging population increases, cardiovascular diseases (CVDs) associated with aging deserve increasing attention. CVD in association with age is considered a major cause of morbidity and mortality worldwide. In this review, we provide an overview of the key molecular pathways, cellular processes such as autophagy, oxidative stress, inflammatory responses, myocardial remodeling and ischemia-refocused injury that accompany CVD as well as the natural products of targeting these mechanisms and some of the dietary habits that have been studied in cardiovascular-related diseases. The potential preventive and therapeutic avenues resulting from these dietary habits and natural products related to animal models and clinical studies can help us to better understand the processes involved in cardiovascular diseases and provide recommendations to reduce the cardiovascular burden associated with aging heart.
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