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Visual Function Measurements in Eyes With Diabetic Retinopathy: An Expert Opinion on Available Measures
Adam R Glassman1, Mohamed Ashraf Elmasry2,3, Darrell E Baskin4
1Jaeb Center for Health Research, Tampa, Florida.
Ophthalmology Science
|June 17, 2024
Summary
Diabetic retinopathy impairs vision, but current tests like BCVA are limited. New visual function tests show promise for early detection and staging of diabetic retinopathy.
Area of Science:
- Ophthalmology
- Diabetic Retinopathy Research
- Visual Function Assessment
Background:
- Diabetic retinopathy (DRD) significantly impacts patient quality of life.
- Best-corrected visual acuity (BCVA) is a standard measure but is insensitive to early DRD.
- BCVA does not capture all visual disturbances experienced by diabetic patients.
Purpose of the Study:
- To evaluate the relationship between diabetic retinal disease (DRD) and various visual function parameters.
- To identify potential visual function tests for a future DRD staging system.
Main Methods:
- Reviewed 7 visual function variables with preliminary data: microperimetry, static automated perimetry, electroretinogram (ERG) oscillatory potentials, flicker ERG, low luminance visual acuity (LLVA), contrast sensitivity (CS), and BCVA.
- Included the objective field analyzer (OFA) after workshops.
Main Results:
- BCVA is the only currently available visual function test.
- LLVA, CS, flicker ERG, and OFA show potential for screening and research.
- Other tested parameters are considered promising (within 5 years) or potential ( >5 years) for clinical use.
Conclusions:
- Current visual function tests show promise beyond BCVA.
- Prospective studies are needed to validate these tests for clinical use and as endpoints in clinical trials for DRD.
