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Cabotegravir + Rilpivirine Long-Acting: Overview of Injection Guidance, Injection Site Reactions, and Best Practices
Paula Teichner1, Nadine Chamay2, Emilie Elliot3
1ViiV Healthcare, Durham, North Carolina, USA.
Open Forum Infectious Diseases
|June 17, 2024
Summary
Long-acting cabotegravir (CAB) + rilpivirine (RPV) injections are well-tolerated for HIV-1 suppression. Healthcare providers identified techniques like slow injection speed and room temperature medication to minimize injection site reactions.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Medicine
Background:
- Cabotegravir (CAB) + rilpivirine (RPV) is a long-acting (LA) injectable regimen for maintaining HIV-1 virologic suppression.
- Injection site reactions (ISRs) are the most common adverse events associated with this regimen.
Purpose of the Study:
- To characterize ISRs and outcomes in patients receiving CAB + RPV LA.
- To identify optimal injection techniques from healthcare provider (HCP) surveys to minimize discomfort.
Main Methods:
- Pooled data from FLAIR and ATLAS-2M studies for ISR characteristics and outcomes up to week 96.
- Anonymous online surveys of HCPs regarding injection techniques and patient comfort.
Main Results:
- 8453 ISRs reported in 801 participants; 99% were mild-to-moderate (grade 1-2) with a median duration of 3 days.
- 181 HCPs surveyed identified slow injection speed, room temperature medication, and gluteal muscle relaxation as effective pain-minimizing techniques.
- Prone positioning was preferred by 60% of HCPs for patient comfort.
Conclusions:
- CAB + RPV LA injections demonstrate favorable long-term tolerability.
- Simple, routinely used techniques can optimize CAB + RPV LA injection administration and patient comfort.
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