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Updated: May 11, 2026

Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
The novel up/down-conversion dual-emission carbon dots for dual-channel ratiometric fluorescence detection of pH and
Yulin Zhu1, Mengqi Zhu1, Qiuju Zhou1
1Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, P. R. China.
Abstract:
Up/down-conversion dual-emission carbon dots (U/D-CDs) are rare and have potential in analytical sensing. Herein, a kind of novel U/D-CDs was prepared successfully by a one-step solvothermal method. The prepared U/D-CDs exhibited similar dual-emission behaviors at excitation wavelengths of 300 nm and 680 nm, respectively. In addition, U/D-CDs displayed good photostability and salt-resistance. Due to the protonation-deprotonation, U/D-CDs showed strong pH dependence in the pH range of 2.0-8.0, which developed an up/down-conversion dual-channel ratiometric fluorescence (FL) probe of pH. The FL intensity of U/D-CDs can be effectively quenched by Cu2+ through the static quenching effect. Meanwhile, an obvious color change from yellow-green to blue can be observed under ultraviolet light with the increase of Cu2+ concentration. The up/down-conversion dual-channel ratiometric fluorescence sensor can be used for the visual sensing of pH and Cu2+, which also eliminates background signals and improves its accuracy and selectivity in complex samples.
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