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Updated: Jun 23, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Circulating immune cells and vitiligo: a bidirectional two-sample Mendelian randomization study.

Yu Xin1, Tao Yuan1, Jun Wang1

  • 1Department of Dermatology, Yijishan Hospital affiliated with Wannan Medical College, Wuhu, China.

Frontiers in Immunology
|June 18, 2024
PubMed
Summary
This summary is machine-generated.

Vitiligo risk is linked to increased levels of basophils, monocytes, eosinophils, and neutrophils. This study clarifies the connection between circulating immune cells and vitiligo pathogenesis.

Keywords:
Mendelian randomizationcirculating immune cellsimmuneoriginal articlevitiligo

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Area of Science:

  • Immunology
  • Genetics
  • Dermatology

Background:

  • Vitiligo pathogenesis is not fully understood.
  • Evidence suggests vitiligo is an immune-mediated disorder.
  • The role of circulating immune cells in vitiligo is unclear.

Purpose of the Study:

  • To investigate the association between circulating immune cells and vitiligo risk.
  • To explore the genetic links between immune cell levels and vitiligo.

Main Methods:

  • Mendelian randomization (MR) analysis was used.
  • Genome-wide association study (GWAS) data for immune cell traits (Blood Cell Consortium) and vitiligo (Finnish GWAS) were analyzed.
  • Inverse variance weighted (IVW) method was the primary analytical approach.

Main Results:

  • Increased risk of vitiligo was associated with higher levels of basophils, monocytes, eosinophils, and neutrophils.
  • Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each cell type.
  • Sensitivity analyses confirmed no significant heterogeneity or pleiotropy.

Conclusions:

  • Circulating immune cells are significantly associated with vitiligo.
  • Findings provide insights into vitiligo's immune basis.
  • Results may inform future clinical strategies for vitiligo treatment.