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Updated: Jun 23, 2025

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Bismuth(III) triflate: an economical and environmentally friendly catalyst for the Nazarov reaction
Manoel Trindade Rodrigues1, Aline Silva Barroso de Oliveira1, Ralph C Gomes1
1Institute of Chemistry, Universidade Estadual de Campinas, PO Box 6154, 13083-970 Campinas, São Paulo, Brazil.
Abstract:
We describe the use of bismuth(III) triflate as an efficient and environmentally friendly catalyst for the Nazarov reaction of aryl vinyl ketones, leading to the synthesis of 3-aryl-2-ethoxycarbonyl-1-indanones and 3-aryl-1-indanones. By changing the temperature and reaction time, it was possible to modulate the reactivity, allowing the synthesis of two distinct product classes (3-aryl-2-ethoxycarbonyl-1-indanones and 3-aryl-1-indanones) in good to excellent yield. The reaction did not require additives and was insensitive to both air and moisture. Preliminary biological evaluation of some indanones showed a promising profile against some human cancer line cells.
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