Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

84
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
84
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

81
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
81
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

80
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
80
Dialysis01:27

Dialysis

288
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
288
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

363
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
363
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

420
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
420

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Communication Experiences of Patients With Hearing Loss During Hemodialysis Treatment and the Potential Role of Communication Tools: A Qualitative Study.

Canadian journal of kidney health and disease·2026
Same author

Evolving Roles for Patients as Partners in a National Kidney Health Research Network: A Qualitative Study.

Health expectations : an international journal of public participation in health care and health policy·2026
Same author

Integrated, Community-Led, Culturally Safe Implementation of a Chronic Kidney Disease Detection Program for Indigenous Communities of Canada: The Kidney Check Program Report.

Canadian journal of kidney health and disease·2026
Same author

Patient and Healthcare Provider Priorities for Risk Prediction of Hospital Readmission: A Nominal Group Technique Consensus Study.

Journal of general internal medicine·2026
Same author

Advancing Equity, Diversity, Inclusion, and Accessibility in a Patient-Oriented Kidney Research Network: A Can-SOLVE CKD Program Report.

Canadian journal of kidney health and disease·2026
Same author

Hearing Loss and Communication Difficulty in Hospital and Hemodialysis Care Settings.

JAMA network open·2026

Related Experiment Video

Updated: Jun 23, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

548

Collaborative implementation science: a Can-SOLVE CKD case example.

Selina Allu1,2, Mary Beaucage1, Maoliosa Donald3

  • 1Can-SOLVE CKD, Vancouver, BC, Canada.

JBI Evidence Implementation
|June 18, 2024
PubMed
Summary
This summary is machine-generated.

Bridging the gap between research and practice requires tailored tools. This study developed an Implementation Toolkit and Pathway to Implementation guide to aid research teams in applying evidence-based interventions effectively.

More Related Videos

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.2K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K

Related Experiment Videos

Last Updated: Jun 23, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

548
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.2K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K

Area of Science:

  • Health Services Research
  • Implementation Science
  • Translational Research

Background:

  • A significant gap exists between identifying evidence-based interventions and their practical implementation in healthcare.
  • Research teams often possess expertise in evidence generation but lack tailored support for evidence implementation.
  • Effective implementation strategies necessitate customization for specific end-users and contexts.

Purpose of the Study:

  • To develop practical tools, an "Implementation Toolkit" and a "Pathway to Implementation" guide.
  • To support research teams and their partners in the critical phase of intervention implementation.
  • To address the need for customized resources in translating research into practice.

Main Methods:

  • Co-creation of tools with diverse stakeholders, including patient partners, implementation experts, researchers, operational leaders, and policymakers.
  • Incorporation of multi-group feedback to ensure relevance and applicability.
  • Development of widely applicable resources for various research teams and interventions.

Main Results:

  • Successful creation of an "Implementation Toolkit" and a "Pathway to Implementation" guide.
  • Tools designed to be adaptable to diverse research settings and intervention types.
  • Resources developed through collaborative input from key stakeholders in health intervention implementation.

Conclusions:

  • The developed tools provide customized support for research teams facing implementation challenges.
  • These resources facilitate the translation of evidence-based interventions into real-world practice.
  • The collaborative development process ensures the broad applicability and utility of the implementation support tools.