Cutaneous metastases: From epidemiology to therapy

Area of Science:

• Oncology
• Dermatology
• Cancer Research

Background:

• Cutaneous metastases are a significant clinical manifestation in oncology, affecting up to 10% of cancer patients.
• These skin metastases can lead to substantial psychological distress, including shame and social withdrawal, particularly when exulcerated.
• The location and presentation of cutaneous metastases vary depending on the primary cancer type.

Purpose of the Study:

• To provide a comprehensive overview of the diagnostic approaches for cutaneous metastases.
• To review current local and systemic therapeutic options for managing skin metastases.
• To discuss the most common primary tumor entities associated with cutaneous metastases.

Main Methods:

• Literature review of diagnostic and therapeutic strategies for cutaneous metastases.
• Analysis of current research on treatment options based on tumor entity.
• Synthesis of information on the psychological impact and management.

Main Results:

• Cutaneous metastases represent a common occurrence in cancer patients, with diverse clinical presentations.
• Effective diagnostic tools are available to identify skin involvement accurately.
• A range of local and systemic treatments can be employed, tailored to the specific cancer type and patient.

Conclusions:

• Accurate diagnosis and timely management of cutaneous metastases are crucial for improving patient outcomes and quality of life.
• Multidisciplinary approaches are often necessary for optimal treatment planning.
• Further research into novel therapeutic strategies is warranted to address the challenges posed by skin metastases.