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Related Concept Videos

Immunological Memory01:23

Immunological Memory

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cell-mediated Immune Responses01:40

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Updated: Jun 23, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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Human CD127 negative ILC2s show immunological memory.

Laura Mathä1,2, Lisette Krabbendam3,4, Sergio Martinez Høyer1

  • 1Microbiology, Tumor and Cell Biology, Karolinska Institute , Stockholm, Sweden.

The Journal of Experimental Medicine
|June 18, 2024
PubMed
Summary
This summary is machine-generated.

Human innate lymphoid cells type 2 (ILC2s) can develop immunological memory, similar to mice. Activated human ILC2s persist, showing reduced CD127 expression and enhanced responses, suggesting a need to revise ILC2 identification strategies.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Innate lymphoid cells type 2 (ILC2s) are crucial for type 2 immunity and tissue homeostasis.
  • ILC2s are implicated in type 2 inflammation-associated conditions like asthma.
  • The existence of immunological memory in human ILC2s remains unconfirmed, unlike in mice.

Purpose of the Study:

  • To investigate whether human ILC2s can acquire immunological memory.
  • To identify markers and characteristics of memory-like human ILC2s.
  • To assess the functional capabilities of these putative memory ILC2s.

Main Methods:

  • Analysis of CD45RO and CD127 expression on resting human ILC2s post-activation.
  • Isolation and in vitro stimulation of CD127-CD45RO+ ILC2s.
  • Gene expression profiling of CD127-CD45RO+ ILC2s.
  • Comparison with mouse memory ILC2 characteristics.

Main Results:

  • Persistent CD45RO expression and reduced CD127 expression were observed in previously activated resting human ILC2s.
  • Isolated CD127-CD45RO+ ILC2s exhibited enhanced proliferation and cytokine production upon stimulation.
  • These memory-like ILC2s were found in both healthy and inflamed tissues and showed an activated gene signature.
  • Reduced CD127 expression was also noted in mouse memory ILC2s.

Conclusions:

  • Human ILC2s possess the capacity to acquire innate immune memory.
  • The CD127-CD45RO+ phenotype represents a potential marker for human memory ILC2s.
  • These findings necessitate a re-evaluation of current methods for identifying human ILC2s.