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Inhibition of prolipoprotein signal peptidase by globomycin
The Journal of Biological Chemistry
|May 25, 1985
Abstract:
Globomycin inhibits the prolipoprotein-specific signal peptidase activity by binding to the enzyme in a noncompetitive manner (Ki = 36 nM). The Km of prolipoprotein signal peptidase for the prolipoprotein substrate is 6 (+/- 1) microM.
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