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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

428
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.6K
Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Teeth01:15

Teeth

377
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
377
The Bone Matrix01:18

The Bone Matrix

3.1K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Updated: Jun 23, 2025

3D Imaging of PDL Collagen Fibers during Orthodontic Tooth Movement in Mandibular Murine Model
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3D Imaging of PDL Collagen Fibers during Orthodontic Tooth Movement in Mandibular Murine Model

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Dentin Mechanobiology: Bridging the Gap between Architecture and Function.

Xiangting Fu1,2,3, Hye Sung Kim1,2,3

  • 1Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea.

International Journal of Molecular Sciences
|June 19, 2024
PubMed
Summary
This summary is machine-generated.

Teeth withstand high mechanical loads due to dentin

Keywords:
dentindentin-mimicking in vitro platformsmechanobiologymechanosensingmechanotransductionviscoelastic properties

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Area of Science:

  • Biomaterials Science
  • Mechanobiology
  • Dental Research

Background:

  • Dentin's unique structure, including its mineralized matrix and nanofibrous composition, provides essential mechanical support and viscoelastic properties for tooth function.
  • Dentin's architecture, featuring odontoblast processes and compartmentalization, influences sensory perception and acts as a protective barrier for the dentin-pulp complex.
  • Understanding dentin mechanobiology is vital for addressing pain in dentin-associated diseases and advancing dentin-pulp regeneration.

Purpose of the Study:

  • To review how dentin's physical characteristics influence mechanosensing, with a focus on mechano-sensitive ion channels.
  • To explore advanced in vitro models that replicate dentin's physical properties.
  • To provide insights into mechanobiological phenomena and inform mechano-therapeutic strategies for dentinal diseases.

Main Methods:

  • Literature review focusing on dentin's physical properties and mechanobiology.
  • Discussion of mechano-sensitive ion channels involved in dentin's sensory functions.
  • Exploration of in vitro platforms simulating dentin's mechanical environment.

Main Results:

  • Dentin's physical features are key regulators of mechanosensing, particularly through mechano-sensitive ion channels.
  • Advanced in vitro platforms offer novel ways to study dentin mechanobiology.
  • These insights are foundational for developing new treatments for dentinal diseases.

Conclusions:

  • Dentin's structure enables sophisticated mechanosensing and protective functions.
  • Further research using advanced models will illuminate dentin mechanobiology.
  • This knowledge paves the way for innovative mechano-therapeutic approaches for dental conditions.