Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

125
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
125
Types of Toxins01:36

Types of Toxins

1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

966
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
966
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

238
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
238
Pharmacovigilance01:19

Pharmacovigilance

821
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
821
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

92
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
92

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Innovative Screening Panel for Preventing Miscarriages-Perspectives, Guidance and Guidelines.

Antioxidants (Basel, Switzerland)·2026
Same author

AgentMol: Multi-Model AI System for Automatic Drug-Target Identification and Molecule Development.

Methods and protocols·2025
Same author

A Proposal for Research Involving New Biomarkers of Hypertension, Lifestyle, and Environmental Exposure.

Current issues in molecular biology·2025
Same author

Mercury Exposure and Health Effects: What Do We Really Know?

International journal of molecular sciences·2025
Same author

NLRP3 Inflammasome in the Pathogenesis of Miscarriages.

International journal of molecular sciences·2024
Same author

Is Copper Still Safe for Us? What Do We Know and What Are the Latest Literature Statements?

Current issues in molecular biology·2024

Related Experiment Video

Updated: Jun 23, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K

Bisphenol A-What Do We Know? A Global or Local Approach at the Public Health Risk Level.

Angelika Edyta Charkiewicz1, Wioleta Justyna Omeljaniuk2, Jacek Nikliński1

  • 1Department of Clinical Molecular Biology, Medical University of Bialystok, 15-269 Bialystok, Poland.

International Journal of Molecular Sciences
|June 19, 2024
PubMed
Summary
This summary is machine-generated.

Bisphenol A (BPA) exhibits significant toxicity across multiple organ systems, even with minimal human exposure. Further research is crucial to understand its long-term health impacts and inform public health strategies.

Keywords:
biomonitoringbisphenol Arisk assessmentssourcestoxicity

More Related Videos

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.0K
Methods to Test Endocrine Disruption in Drosophila melanogaster
09:43

Methods to Test Endocrine Disruption in Drosophila melanogaster

Published on: July 3, 2019

9.7K

Related Experiment Videos

Last Updated: Jun 23, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K
Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.0K
Methods to Test Endocrine Disruption in Drosophila melanogaster
09:43

Methods to Test Endocrine Disruption in Drosophila melanogaster

Published on: July 3, 2019

9.7K

Area of Science:

  • Environmental Health
  • Toxicology
  • Endocrinology

Background:

  • Bisphenol A (BPA) is a widely used industrial chemical with demonstrated multisystem toxicity in animal models.
  • Human health effects from BPA exposure remain under investigation, despite its ubiquity and ease of bodily penetration.
  • Concerns persist regarding high biomonitoring levels of BPA, posing a potential public health threat.

Purpose of the Study:

  • To comprehensively assess the toxicity and health effects of BPA and its derivatives using existing literature.
  • To review international guidelines and regional policies aimed at reducing BPA in consumer products.
  • To highlight the ongoing controversy and knowledge gaps surrounding BPA's impact on human health.

Main Methods:

  • Systematic literature review of toxicological and epidemiological studies on BPA.
  • Analysis of regulatory documents and guidelines from international health organizations.
  • Evaluation of current biomonitoring data and exposure assessment methodologies.

Main Results:

  • BPA exposure, even at low levels, is linked to various disorders and dysfunctions.
  • The widespread presence of BPA throughout product life cycles facilitates human exposure.
  • Despite extensive study, BPA remains controversial, with high biomonitoring levels indicating persistent public health concerns.

Conclusions:

  • Continued research, particularly in molecular biology and human exposure assessment, is essential to fully understand BPA's risks.
  • Increased global awareness among organizations, companies, and consumers is necessary for informed decision-making regarding BPA and its substitutes.
  • Long-term observation and extensive research are required to address the remaining questions about BPA's health effects.