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Implementing Multifactorial Risk Assessment with Polygenic Risk Scores for Personalized Breast Cancer Screening in

Meghan J Walker^1,2, Kristina M Blackmore¹, Amy Chang¹

¹Ontario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.

|June 19, 2024

Summary

This summary is machine-generated.

Risk-stratified breast screening is feasible in Canada. Implementation requires an equity focus to prevent widening cancer screening disparities, especially for visible minorities and those with lower education.

Keywords:

breast cancer breast cancer screening implementation polygenic risk score risk assessment risk stratification

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Area of Science:

Oncology
Public Health
Health Services Research

Background:

Age-based breast cancer screening has limitations.
Risk-stratified screening offers a personalized approach.
The PERSPECTIVE I&I project provides Canadian data on multifactorial risk assessment.

Purpose of the Study:

To assess the feasibility of multifactorial breast cancer risk assessment in a Canadian population.
To evaluate methods for collecting risk factor information and associated costs.
To inform the implementation of risk-stratified breast screening programs.

Main Methods:

Prospective cohort study of 4246 women aged 40-69 without breast cancer.
Multifactorial breast cancer risk assessment was performed.
Logistic regression analyzed associations between participant characteristics and data collection methods.

Main Results:

88.4% of participants completed risk assessment; 4.4% were high risk.
Per-participant cost for risk assessment was CAD 315.
Paper/telephone data collection was associated with older age, non-Canadian birth, visible minority status, lower education, and poorer perceived health.

Conclusions:

Multifactorial risk assessment is feasible at the population level for risk-stratified screening.
Implementation must address equity to avoid exacerbating cancer screening disparities.
Specific demographic groups require tailored approaches for effective risk factor data collection.