Hydrogel-tissue adhesion by particle bridging: sensitivity to interfacial wetting and tissue composition.
Raphaël Michel1,2, Laurent Corté1,3
1Molecular, Macromolecular Chemistry, and Materials, ESPCI Paris, CNRS, PSL University, 10 rue Vauquelin, 75005, Paris, France. raphael.michel@cermav.cnrs.fr.
Soft Matter
|June 19, 2024
Summary
Particle bridging enhances tissue adhesion by utilizing silica nanoparticles at the hydrogel-tissue interface. This method improves adhesion, especially in hydrated conditions, offering a promising alternative to surgical glues.
Area of Science:
- Biomaterials Science
- Adhesion Science
- Tissue Engineering
Background:
- Solid particles at hydrogel-tissue interfaces can form adhesive joints via macromolecular adsorption.
- Understanding factors influencing particle-bridging adhesion is crucial for developing effective tissue adhesives.
Purpose of the Study:
- To investigate how tissue surface wetting and composition heterogeneity affect particle-bridging adhesion.
- To evaluate the performance of silica nanoparticle-coated hydrogels as tissue adhesives.
Main Methods:
- Ex vivo peeling experiments using poly(ethylene glycol) films with silica nanoparticle aggregates on porcine liver tissue.
- Systematic variation of interfacial fluid conditions to study wetting effects.
- Microscopic observation of detachment mechanisms during peeling.
Main Results:
- Adhesion transitions from lubricated to adhesive contact as interfacial fluid is removed.
- Silica nanoparticle coating enhances adhesion, particularly in hydrated conditions.
- Coated films achieved significantly higher adhesion energy (7.7 J m⁻²) compared to uncoated films (3.2 J m⁻²) and cyanoacrylate glue (2.9 J m⁻²).
- Detachment mechanisms varied based on liver microanatomy, involving particle detachment or cohesive tissue fracture.
Conclusions:
- Interfacial wetting and tissue composition significantly influence particle-bridging adhesion.
- Silica nanoparticle coatings improve hydrogel adhesion to biological tissues.
- Particle bridging offers a tunable strategy for designing advanced tissue adhesives.
Related Concept Videos
01:07Cohesion
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a surface,...
On a surface,...
01:29The Extracellular Matrix
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
01:21Matrix Proteoglycans and Glycoproteins
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
01:03Anchoring Junctions
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
01:24Adherens Junctions
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Adherens Junctions are Dynamic
The endothelial cells...
01:14Cell Adhesion in Plants
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose, and...