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Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Related Experiment Video

Updated: Jun 23, 2025

Colorimetric Analysis of Alkaline Phosphatase Activity in S. aureus Biofilm
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Hypoalkaline Phosphatemia Dental Type: A Case Report.

Weihua Liu1, Xiaoyang Min1, Hongli Wang2

  • 1Department of Pediatrics, Xi'an First Hospital, The First Affiliated Hospital of Northwestern University, China.

Clinical Medicine Insights. Pediatrics
|June 19, 2024
PubMed
Summary

Dental hypophosphatasia (HPP) is rare, often presenting with mild symptoms. This case study details a child with odonto-HPP, identifying two ALPL gene mutations, including a novel one, linked to early tooth loss and low alkaline phosphatase.

Area of Science:

  • Genetics
  • Biochemistry
  • Pediatrics

Background:

  • Dental hypophosphatasia (HPP) is an inherited metabolic disorder characterized by defective bone and tooth mineralization.
Keywords:
ALPL geneAlkaline phosphatasegene mutationhypophosphatasiaodonto hypophosphatasia

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  • Mutations in the ALPL gene encoding tissue-nonspecific alkaline phosphatase (TNSALP) cause HPP.
  • Dental manifestations of HPP are often mild or overlooked, leading to underdiagnosis.